How NAD+ works
NAD+ is an essential coenzyme found in every living cell. It shuttles electrons through the mitochondrial electron transport chain to generate ATP, while also serving as a substrate for sirtuins and PARPs that govern DNA repair, circadian rhythm and inflammatory signalling. Levels decline with age, and restoring them supports the energy and repair programs that slow cellular ageing.
Reported benefits
- Supports mitochondrial ATP production
- Activates sirtuin longevity pathways
- Enhances DNA repair and cellular resilience
- Improves metabolic efficiency and NAD+/NADH ratio
Reported side effects
Effects reported in published trials, case reports or post-market surveillance. Individual response varies; this list is educational and not exhaustive.
- Chest tightness, flushing and nausea when infused or injected too quickly
- Headache and cramping
- Injection-site irritation
- Fatigue after high doses
Regulatory status & sources
Injectable NAD+ is not an FDA-approved drug; oral NAD precursors (NR, NMN) are regulated as supplements and studied in trials.
Safety note
NAD+ is presented here for research and educational purposes only. It is not offered for human consumption and nothing on this page is medical advice or a dosing protocol. Read the full safety and disclaimer page.